Loss of cell identity drives human aging: Two new papers

Automated excerpt

The idea that accumulated damage is the principal pathway for cell aging is now complemented by the loss of cell identity model. A cell sitting down in the valley (Figure below, culled together from the Nature paper) represents a distinct specialized cell. But with aging, the valleys lose their slope, the basin becomes shallow, there is loss of epigenetic constraints, and there is instability of cell identity.

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